Lupus & antiphospholipid syndrome
Systemic lupus erythematosus comorbid with chronic spontaneous urticaria: a multicentre retrospective study
Authors' conclusion
The presence of CSU in patients with SLE does not necessarily indicate increased lupus activity. Rather, cylindruria, mucosal ulcers and elevated IgA and IgG levels were identified as independent risk factors for CSU in patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) with and without chronic spontaneous urticaria (CSU)
- Participants
- 40 vs 160
- Comparison
- SLE with concomitant CSU vs SLE controls without CSU
- SLE-CSUn = 40
- SLE-onlyn = 160reference
- Outcome
- Independent risk factors for CSU in SLE (multivariate logistic regression)
Methodological detailsmulticentre, age-matched and sex-matched controls, multivariate logistic regression
- Multicentre
- Age-matched and sex-matched controls
- Multivariate logistic regression
Main finding
As reported in the abstract
Odds ratio (CI)P value
Cylindruria
6.152(2.352–16.093)
p＜0.001Elevated IgA
7.598(1.194–48.368)
P = 0.032Elevated IgG
3.252(1.331–7.946)
P = 0.010Mucosal ulcers
3.838(1.166–12.637)
P = 0.027Observational data: associations, not effects.
Further findings
Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores before vs after CSU onset (SLE-CSU)
- Occurrence of CSU did not result in an increase of SLEDAI scores
- Wilcoxon signed-rank test
Univariate differences between SLE-CSU and SLE-only
- Significant differences in cylindruria, elevated IgM, IgA, IgG, serositis, mucosal ulcers and anti-Pm-Scl antibodies
- P < 0.05
Original publication
Systemic lupus erythematosus comorbid with chronic spontaneous urticaria: a multicentre retrospective study. Lupus Sci Med. Published 23 December 2025. doi:10.
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