Lupus & antiphospholipid syndrome
Intraindividual cognitive function course over time in patients with systemic lupus erythematosus
Authors' conclusion
This study highlights the variable nature of CI in SLE patients, with most exhibiting a stable course over 1 year.
Study context
- Population
- Adult Systemic Lupus Erythematosus (SLE) patients, University of Toronto Lupus Clinic
- Participants
- 175 patients
- Exposure
- Persistent-CI vs never-CI
- Outcome
- Course of CI (ACR Neuropsychological Battery, standardised z-scores in cognitive domains)
- Follow-up
- 1 year
Methodological detailssingle-centre, assessments at baseline, 6 months and 12 months
- Single-centre
- Assessments at baseline, 6 months and 12 months
Main finding
As reported in the abstract
CI course over 1 year
- Any CI over 1 year
- 46%
Observational data: associations, not effects.
Further findings
CI severity
- Persistent-CI patients exhibited more severe CI compared with fluctuating-CI
Most frequently affected cognitive domains
- Learning and memory, simple attention and processing speed, and visual-spatial construction
Factors associated with CI persistence over 1 year
- Black race, older age at SLE diagnosis, divorced/separated status at T0 and higher disease-related damage at T0
Original publication
Intraindividual cognitive function course over time in patients with systemic lupus erythematosus. RMD Open. Published 23 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →