Sjögren's disease & overlap diseases
Exploring sleep health and circadian rhythm disruption in Sjögren’s disease: an accelerometric and self-reported cross-sectional study
Authors' conclusion
SjD is associated with impaired sleep health and rest-activity rhythms.
Study context
- Population
- Patients with Sjögren's Disease (SjD) and age-, sex- and BMI-matched healthy controls (HCs)matched
- Participants
- 46 vs 40
- Exposure
- SjD patients vs age-, sex- and BMI-matched HCs
- SjDn = 46
- HCsn = 40reference
- Outcome
- Sleep health and rest-activity parameters (7-day accelerometry, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, reduced Morningness-Eveningness Questionnaire; multidimensional sleep health index)
Methodological detailsaccelerometric and self-reported, age-, sex- and BMI-matched controls, functional linear modelling, regression analysis
- Accelerometric and self-reported
- Age-, sex- and BMI-matched controls
- Functional linear modelling
- Regression analysis
Main finding
As reported in the abstract
- Functional linear modelling confirmed the objective shift towards eveningness in SjD patients
- SjD vs HCs: P = 0.005
- SjD vs HCs: P = 0.009
- SjD vs HCs: P = 0.033
Observational data: associations, not effects.
Further findings
Predictors of sleep and rest-activity parameters within SjD (regression)
- Patient-reported disease burden → sleep quality, β
- 0.41; P = 0.044
- Patient-reported disease burden → sleepiness, β
- 0.83; P = 0.010
- Disease activity → daily steps, β
- −526; P = 0.013
- Disease activity → total sleep time, β
- 0.15; P = 0.0496
- Disease activity → sleep regularity, β
- −1.3; P = 0.030
- Hospital Anxiety and Depression Scale (HADS) → daily steps, β
- −238; P = 0.041
- HADS → total sleep time, β
- −0.08; P = 0.035
- HADS → sleep efficiency, β
- −0.65; P = 0.012
Original publication
Exploring sleep health and circadian rhythm disruption in Sjögren’s disease: an accelerometric and self-reported cross-sectional study. Rheumatology (Oxford). Published 21 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →