Evidence of Site‐Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis
Authors' conclusion
Our study shows the presence of ACPA, anti-CarP, and AAPA IgA in saliva of ACPA-seropositive patients with RA. However, no AMPA could be detected in feces/ileal wash samples of these patients, although our assays were able to measure other antigen-specific antibodies.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and healthy volunteers, two independent cohorts plus a third cohort for feces
- Exposure
- Patients with RA vs healthy volunteers; Anti-modified protein antibodies (AMPA) in saliva vs feces/ileal wash
- Outcome
- Presence of AMPA (ACPA, anti-CarP, AAPA) at different mucosal sites, including the intestinal tract
Methodological detailspaired fecal/ileal wash, saliva and serum samples, two independent cohorts, fecal data replicated in a third cohort, in-house ELISA with unmodified peptides as control
- Paired fecal/ileal wash, saliva and serum samples
- Two independent cohorts
- Fecal data replicated in a third cohort
- In-house ELISA with unmodified peptides as control
Main finding
As reported in the abstract
AMPA IgA at mucosal sites
Anti-citrullinated protein antibodies (ACPA), anti-CarP and AAPA IgA measurable in saliva of seropositive patients with RA (prevalence)
9%-40%
Observational data: associations, not effects.
Original publication
Evidence of Site‐Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis. Arthritis Rheumatol. Published 18 November 2024. doi:10.
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