Smoking-related bias of standardized mortality ratios in rheumatoid arthritis: A modeling study
Authors' conclusion
SMRs in RA may be inflated by even small increases in the prevalence of smoking relative to the general population.
Study context
- Population
- Hypothetical cohorts from US National Health Interview Surveys 1999–2004 with age-sex composition typical of rheumatoid arthritis (RA) (age 30 to 79; 70 % women)
- Comparison
- Simulated RA cohorts with higher smoking prevalence (smoking RR 1.25, 1.5, 1.75, 2.0) vs reference cohort with general-population smoking prevalence
- Outcome
- SMR for RA (mortality in higher-smoking simulated RA cohorts vs reference cohort)
- Follow-up
- 10 years and 15 years
Methodological detailshypothetical cohorts, 2000 replicate samples
- Hypothetical cohorts
- 2000 replicate samples
Main finding
As reported in the abstract
Median SMR for RA
Median SMR
- RA cohort, smoking RR 2.0 vs Reference · at 10 years
- 1.23
- RA cohort, smoking RR 2.0 vs Reference · at 15 years
- 1.17
- RA cohort, smoking RR 1.25 vs Reference · at 10 years
- 1.07
- RA cohort, smoking RR 1.25 vs Reference · at 15 years
- 1.04
Further findings
Standardized mortality ratios (SMRs) based on RRs comparing ever smokers to never smokers
- Results were similar
Differences in smoking intensity
- Small effects on SMRs
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Smoking-related bias of standardized mortality ratios in rheumatoid arthritis: A modeling study. Semin Arthritis Rheum. Published 17 November 2024. doi:10.
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