Mitophagy drives maldifferentiation of tissue-resident memory T cells in patients with rheumatoid arthritis
Authors' conclusion
Mitophagy is elevated in RA T cells, leading to maldifferentiation of Trm cells in RA patients.
Study context
- Population
- T cells from rheumatoid arthritis (RA) patients and age- and sex-matched healthy individuals; humanized RA chimeras
- Participants
- 94 vs 37
- Comparison
- RA patients vs age- and sex-matched healthy individuals; mitophagy inhibition in humanized RA chimeras
- RAn = 94
- Healthy individualsn = 37reference
Methodological detailsage- and sex-matched healthy controls, humanized RA chimeras
- Age- and sex-matched healthy controls
- Humanized RA chimeras
Main finding
As reported in the abstract
- T cells exerted high levels of mitophagy in RA patients
- Mitophagy had a significant impact on differentiation of Trm cells, but not Th1 or Th17 cells
- Inhibiting mitophagy significantly reduced the number of Trm cells and downregulated inflammatory responses (diminished T cell receptor β, interferon-γ and IL-17A) in humanized RA chimeras
Original publication
Mitophagy drives maldifferentiation of tissue-resident memory T cells in patients with rheumatoid arthritis. Scand J Rheumatol. Published 15 November 2024. doi:10.
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