Detecting new erosions in rheumatoid arthritis over one year – Radiography and high-resolution computed tomography of finger joints
Authors' conclusion
HR-pQCT identified more than 20 times the number of new erosions, and more than 10 times as many patients with erosive progression than CR.
Study context
- Population
- Patients with RA with paired high-resolution peripheral quantitative computed tomography (HR-pQCT) and conventional radiography (CR) of the 2nd and 3rd metacarpophalangeal (MCP) joints of the dominant hand at baseline and one-year follow-up
- Participants
- 310 paired image sets
- Comparison
- CR vs HR-pQCT for detecting new erosions and erosive progression in 2nd and 3rd MCP joints of the dominant hand over one year
- Outcome
- Number of new erosions in two MCP joints by HR-pQCT vs CR
- Follow-up
- One year
Methodological detailspaired imaging, HR-pQCT as reference standard
- Paired imaging
- HR-pQCT as reference standard
Performance
As reported in the abstract
New erosions
CR
3
events
HR-pQCT
66
events
Further findings
| Outcome | Values |
|---|---|
| Erosions at baseline | CR 250 events · HR-pQCT 1864 events |
| Patients with erosive progression · one year | HR-pQCT 40 events |
| Diagnostic accuracy of CR for erosive progression (HR-pQCT as reference) · one year | CR sensitivity 2.5% (95% CI: 0.1-13.2%) · specificity 99.3% (95% CI: 97.3-99.9%) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Detecting new erosions in rheumatoid arthritis over one year – Radiography and high-resolution computed tomography of finger joints. Joint Bone Spine. Published 14 November 2024. doi:10.
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