The Minimal Erosive Volume Needed for Radiographic Identification of Erosions in the Metacarpophalangeal Joints in Patients With Rheumatoid Arthritis
Authors' conclusion
Erosions by HR-pQCT were larger in patients with erosive damage in the second and third MCP joints by CR. We found that CR had poor sensitivity for detecting erosive disease when the erosive volume was < 56.4 mm3 or the number of erosions was < 8.5.
Study context
- Population
- Patients with established RA (disease duration ≥ 5 yrs); second and third metacarpophalangeal (MCP) joints of the dominant hand by high-resolution peripheral quantitative computed tomography (HR-pQCT) and conventional radiography (CR)
- Exposure
- HR-pQCT erosive volume and erosion count vs CR-detected erosive disease, second and third MCP joints
- Outcome
- Optimal cut-off of HR-pQCT total erosive volume and number of erosions for CR-detected erosive disease in the second and third MCP joints
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
HR-pQCT cut-offs for CR-detected erosive disease, second and third MCP joints
| Group | Value | Sensitivity | Specificity | AUC |
|---|---|---|---|---|
| HR-pQCT total erosive volume | 56.4 (95% CI 3.5–109.3) mm³ | 78% | 83% | 0.81 |
| HR-pQCT number of erosions | 8.5 (95% CI 5.9–11.1) | 74% | 88% | 0.81 |
Value
HR-pQCT total erosive volume56.4 (95% CI 3.5–109.3) mm³
HR-pQCT number of erosions8.5 (95% CI 5.9–11.1)
Sensitivity
HR-pQCT total erosive volume78%
HR-pQCT number of erosions74%
Specificity
HR-pQCT total erosive volume83%
HR-pQCT number of erosions88%
AUC
HR-pQCT total erosive volume0.81
HR-pQCT number of erosions0.81
Observational data: associations, not effects.
Original publication
The Minimal Erosive Volume Needed for Radiographic Identification of Erosions in the Metacarpophalangeal Joints in Patients With Rheumatoid Arthritis. J Rheumatol. Published 15 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →