Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations
Authors' conclusion
AMPA against various post-translational modifications could consistently be detected on different continents across ethnically diverse RA populations. Differences in AMPA levels corresponded to differences in total serum IgG levels.
Study context
- Population
- ACPA-positive rheumatoid arthritis (RA) patients in four ethnically diverse populations on four continents
- Participants
- 103 / 174 / 100 / 67
- Exposure
- Anti-modified protein antibodies (AMPA) seropositivity across Dutch, Japanese, First Nations Canadian and black South African RA patients
- NLn = 103
- Japanese (JP)n = 174
- FNn = 100
- South African (SA)n = 67
- Outcome
- AMPA (anti-CarP, anti-malondialdehyde acetaldehyde (anti-MAA), anti-AcVim IgG) prevalence and association with HLA DRB1 alleles and smoking
Methodological detailsmulticentre, four ethnically diverse populations on four continents, ethnicity-matched local healthy controls for cut-offs, logistic regression
- Multicentre
- Four ethnically diverse populations on four continents
- Ethnicity-matched local healthy controls for cut-offs
- Logistic regression
Main finding
As reported in the abstract
Anti-CarP seropositivity
P < 0.001
Observational data: associations, not effects.
Further findings
Anti-MAA seropositivity · across NL, JP, FN and SA
P < 0.001
Anti-AcVim seropositivity · across NL, JP, FN and SA
P < 0.001
Total IgG and IgG-normalised autoantibody levels
- Total IgG levels differed markedly; after normalisation to total IgG, differences between cohorts less pronounced
Association of AMPA with HLA risk alleles and smoking
- Some associations, none consistent across all four cohorts
Original publication
Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations. Arthritis Res Ther. Published 8 March 2023. doi:10.
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