Rheumatoid arthritis

Estimating the incidence of autoimmune inflammatory arthritis after Lyme disease

Semin Arthritis RheumPublished Retrospective cohort study

Main finding · Incidence of IAResult — go to the resultOdds ratio 3.76 95 % CI 2.41–5.86

Authors' conclusion

The incidence of IA was higher within a year of LD infection, higher than that expected in the general population.

Study context

Population
Patients with Lyme disease (LD) or influenza in Johns Hopkins Health System administrative claims data, 01/2013–05/2024
Exposure
Lyme disease vs influenza
Outcome
Incidence of IA (2+ ICD codes for RA, PsA or SpA) after infection
Follow-up
Within 2 years
Methodological detailsadministrative claims data, logistic regression adjusted for age and sex
  • Administrative claims data
  • Logistic regression adjusted for age and sex

Main finding

Incidence of IA

Odds ratio

3.76

95 % CI 2.41–5.86

P < 0.001

By group

LDvs Influenza
OR 3.76 (95 % CI 2.41–5.86); P < 0.001

As reported in the abstract

Observational data: associations, not effects.

Original publication

Estimating the incidence of autoimmune inflammatory arthritis after Lyme disease. Semin Arthritis Rheum. Published 16 July 2025. doi:10.1016/j.semarthrit.2025.152797

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