Lupus & antiphospholipid syndrome
Estimating glucocorticoid-related morbidity in lupus nephritis using the glucocorticoid toxicity index
Authors' conclusion
In this cohort study, the GTI was associated with cumulative steroid exposure at 5 years after diagnosis.
Study context
- Population
- Patients with biopsy-confirmed lupus nephritis (LN), 2006–2016 (mean age 33.3 years)
- Participants
- 49 patients
- Exposure
- Association of cumulative GC exposure with glucocorticoid toxicity index (GTI) scores
- Outcome
- Association between cumulative GC exposure and GTI scores (GTI-AIS and GTI-CWS)
- Follow-up
- 1 year and 5 years after kidney biopsy
Methodological detailslinear regression
- Linear regression
Main finding
As reported in the abstract
Association of GC exposure with GTI scores · 5 years
- Higher GC exposure associated with higher GTI-AIS
- p < 0.001
- Higher GC exposure associated with higher GTI-CWS
- p = 0.002
- Multivariate (age, sex, race, induction medication, nephritis class): GTI-AIS
- p = 0.026 for AIS
- Multivariate (age, sex, race, induction medication, nephritis class): GTI-CWS
- p = 0.012 for CWS
Observational data: associations, not effects.
Further findings
Association of GC exposure with GTI scores · 1 year
- GC exposure not associated with GTI-AIS
- P = 0.70 for AIS
- GC exposure not associated with GTI-CWS
- P = 0.58 for CWS
Mean GC exposure (mg prednisone-equivalents per day)
- Through year 1
- 23.0
- Through year 5
- 9.9
Original publication
Estimating glucocorticoid-related morbidity in lupus nephritis using the glucocorticoid toxicity index. Lupus. Published 24 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →