Lupus & antiphospholipid syndrome
Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling
Authors' conclusion
Patients with new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs.
Study context
- Population
- Systemic Lupus International Collaborating Clinics inception cohort of patients with systemic lupus erythematosus (SLE) (49% White race/ethnicity)mean follow-up 9.6 years
- Participants
- 1,697 participants
- Exposure
- New/ongoing neuropsychiatric (NP) event vs no NP event
- Outcome
- Direct and indirect costs associated with NP events (annual; predicted 5- and 10-year costs per NP state)
Methodological detailsmultistate modeling, random-effects regressions
- Multistate modeling
- Random-effects regressions
Main finding
As reported in the abstract
Direct costs higher in new/ongoing vs no events (fold)
1.5
Indirect costs higher in new/ongoing vs no events (fold)
1.3
Indirect costs exceeded direct costs (fold)
3.0 to 5.2
Observational data: associations, not effects.
Further findings
NP events
- NP events
- 1,971
- Patients with NP events
- 956
- NP events attributed to SLE
- 32%
Largest cost increases by NP event type
- SLE NP events: new/ongoing seizure disorder and cerebrovascular disease accounted for the largest increases in annual direct costs
- Non-SLE NP events: new/ongoing polyneuropathy largest increase in annual direct costs; new/ongoing headache and mood disorder largest increases in indirect costs
Original publication
Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling. Arthritis Care Res (Hoboken). Published 23 February 2023. doi:10.
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