Spondyloarthritis & psoriatic arthritis

Enhancing diagnostic accuracy in axial spondyloarthritis through centralised clinical and imaging evaluation: results from a prospective multicentre project

Ann Rheum DisPublished Prospective multicentre diagnostic study

Authors' conclusion

Remote evaluation of clinical and imaging information by assessors with expertise in axSpA may support the diagnostic process in patients with suspected axSpA and help reduce the risk of misdiagnosis.

Study context

Population
Patients presenting to rheumatologists and orthopaedists with suspected axial spondyloarthritis (axSpA)cases of suspected axSpA
Participants
969 patients
Comparison
Local diagnostic assessment vs centralised expert clinical and imaging evaluation
Outcome
Impact of centralised clinical and imaging evaluation on diagnostic assessment of suspected axSpA (presence or absence of axSpA)
Methodological detailscentral telemedicine platform, remote central expert evaluation
  • Central telemedicine platform
  • Remote central expert evaluation

Performance

As reported in the abstract

axSpA diagnosis

Further findings

Central evaluation among local axSpA diagnoses

Confirmed as axSpA by central evaluation
142 (53.8%)
Alternative cause of back pain (most commonly degenerative or mechanical) considered more likely
89 (33.7%)

Central evaluation among 319 locally assessed as no axSpA

Considered no axSpA by central reviewers
265 (83.1%)

Drivers of discrepancy

Interpretation of imaging findings as indicative of axSpA or not was a main driver of local–central discrepancy

Original publication

Enhancing diagnostic accuracy in axial spondyloarthritis through centralised clinical and imaging evaluation: results from a prospective multicentre project. Ann Rheum Dis. Published 9 July 2026. doi:10.1016/j.ard.2026.06.019

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