Enhancement of Intracellular Cholesterol Efflux in Chondrocytes Leading to Alleviation of Osteoarthritis Progression
Authors' conclusion
Our results suggest that restoration of cholesterol homeostasis to a normal state through administration of fenofibrate or AIBP overexpression, both of which induce cholesterol efflux, offers an effective therapeutic option for patients with OA.
Study context
- Population
- Mice with osteoarthritis (OA) induced by destabilization of the medial meniscus and fed a 2% high-cholesterol diet; humans (lipid profiles and OA)
- Comparison
- Five cholesterol-lowering drugs in mice with OA
Methodological detailshuman logistic regression analysis, mouse DMM-induced OA model with 2% high-cholesterol diet, microarray analysis, intra-articular injection of inhibitor or adenovirus
- Human logistic regression analysis
- Mouse DMM-induced OA model with 2% high-cholesterol diet
- Microarray analysis
- Intra-articular injection of inhibitor or adenovirus
Main finding
As reported in the abstract
- Close relationship between hyperlipidemia diagnostic criteria (serum lipid levels) and OA incidence (logistic regression)
- Fenofibrate exerted the most significant protective effect against cartilage destruction among the drugs, attributed to elevated HDL cholesterol crucial for cholesterol efflux
- Cholesterol efflux suppressed during OA progression via down-regulation of AIBP expression
- Overexpression of AIBP inhibits OA progression
Original publication
Enhancement of Intracellular Cholesterol Efflux in Chondrocytes Leading to Alleviation of Osteoarthritis Progression. Arthritis Rheumatol. Published 29 September 2024. doi:10.
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