Endocrine dysfunction in patients with juvenile idiopathic arthritis
Authors' conclusion
One third of JIA patients experience growth and pubertal disturbances, primarily due to altered GH-IGF1 axis.
Study context
- Population
- Children with JIA (revised ILAR criteria), disease duration >6 months, Rheumatology department, KGMU, India, July 2021–January 202372 boys & 35 girls
- Participants
- 107 children
- Outcome
- Prevalence of endocrine dysfunction (growth and sexual development)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prevalence of growth and pubertal disturbances · baseline
Stunted
20.6%
Underweight
22.4%
Low BMI
25.2%
Delayed puberty
2.8%
Observational data: associations, not effects.
Further findings
Factors associated with stunting
- Stunted children more likely to have early onset
- P = 0.015
- Stunted children more likely to have high GH level
- P = 0.013
Factors associated with underweight
- Underweight children had longer disease
- P = 0.047
- Underweight children had more damage
- P = 0.006
- Children with weight z < −2 have high GH and low IGFBP3
Factors associated with low BMI
- Low BMI group had high disease activity, damage, and poor quality of life & functional state
- P = < 0.01
Estradiol in girls
- Girls with low Estradiol level had longer exposure to corticosteroids
Slower growth velocity · one year
- Slower growth velocity without any identifiable cause
- 22.4%
Original publication
Endocrine dysfunction in patients with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. Published 24 April 2025. doi:10.
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