Unmet needs and research gaps in Still’s disease across ages: proceedings from a pediatric and adult joint expert panel
Methodological detailspediatric and adult joint expert panel, supplemented by relevant literature, Four topics discussed: early recognition and diagnosis; pathogenetic pathways and biomarkers; refractory disease and risk factors; treatment of SD and its complications
- Pediatric and adult joint expert panel
- Supplemented by relevant literature
- Four topics discussed: early recognition and diagnosis; pathogenetic pathways and biomarkers; refractory disease and risk factors; treatment of SD and its complications
Recommendations
As issued by the authors
Improved diagnostic criteria and validation of biomarkers are important steps towards early diagnosis; several biomarkers remain to be universally validated and available for clinical practice
Awareness of important complications, including macrophage activation syndrome and lung disease, is crucial for improving outcomes, alongside better understanding of risk factors for refractory disease
IL-1 and IL-6 inhibitors have improved treatment; harmonizing the therapeutic approach across centers and countries and developing strategies for refractory patients remain a challenge
Original publication
Unmet needs and research gaps in Still’s disease across ages: proceedings from a pediatric and adult joint expert panel. Pediatr Rheumatol Online J. Published 23 April 2025. doi:10.
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