Infant-onset juvenile idiopathic arthritis: a multicentre retrospective study
Authors' conclusion
Very early-onset JIA is often diagnosed late, delaying appropriate care.
Study context
- Population
- Infants with juvenile idiopathic arthritis (JIA) in the German National Pediatric Rheumatology Database (NPRD), 2011–2020, 18 pediatric rheumatology centres in Germany; disease onset at 9.5 ± 2.64 months; 62% femaleinfant-onset JIA
- Participants
- 90 infants
- Exposure
- Infant-onset JIA vs matched toddler-onset JIA
- Infant-onset JIAn = 90
- Outcome
- Time from symptom onset to first rheumatology consultation
Methodological detailsmulticentre, matched comparison cohort, German National Pediatric Rheumatology Database (NPRD), prospective follow-up supplemented retrospectively
- Multicentre
- Matched comparison cohort
- German National Pediatric Rheumatology Database (NPRD), prospective follow-up supplemented retrospectively
Main finding
As reported in the abstract
Significantly longer in infants than toddlers (infants vs toddlers)
3.1 vs 2.3 months
P = 0.025
Observational data: associations, not effects.
Further findings
DMARDs prescribed · follow-up
| Outcome | Infant-onset JIA | Toddler-onset JIA | P value |
|---|---|---|---|
| Disease activity (cJADAS10) · follow-upSignificantly higher in infants | 3.0 | 2.1 | P = 0.034 |
Systemic JIA
- Infants more frequently affected by systemic JIA than toddlers
Disease activity · enrolment
- Similar disease activity in both groups at enrolment
Original publication
Infant-onset juvenile idiopathic arthritis: a multicentre retrospective study. Rheumatology (Oxford). Published 4 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →