Elevated serum soluble CD27 levels are associated with both disease activity and humoral immune activity in patients with rheumatoid arthritis
Authors' conclusion
Serum sCD27 might be a promising biomarker that reflects both disease activity and humoral immunity activity in RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA), idiopathic inflammatory myopathy (IIM), systemic lupus erythematosus (SLE) and healthy controls
- Exposure
- RA vs IIM, SLE and healthy controls
- Outcome
- Serum sCD27 levels
Methodological detailsELISA
- ELISA
Main finding
As reported in the abstract
p 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| sCD27 by RF status in RA (subgroup) | RF-positive 6054 ± 5842 pg/mL · RF-negative 3902 ± 2098 pg/mL | |
| sCD27 by anti-CCP status in RA (subgroup) | Anti-CCP-positive 5810 ± 5671 pg/mL · Anti-CCP-negative 4183 ± 2187 pg/mL | |
| ESR, RF, IgA, IgG and DAS28-CRP by sCD27 level in RAHigher sCD27 vs Lower sCD27 · elevated with higher sCD27 | P < 0.01 |
Correlates of serum soluble CD27 (sCD27) in RA
- sCD27 correlated with age, ESR, C-reactive protein (CRP), rheumatoid factor (RF), IgA, IgG, complement 4 and DAS28 in RA
sCD27 by RF status in RA (subgroup)
- Higher in RF-positive than RF-negative
sCD27 by anti-cyclic citrullinated peptide (anti-CCP) status in RA (subgroup)
- Similar finding (higher in anti-CCP-positive)
Original publication
Elevated serum soluble CD27 levels are associated with both disease activity and humoral immune activity in patients with rheumatoid arthritis. Clin Exp Rheumatol. Published 4 April 2023. doi:10.
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