Elevated DAS28-ESR in patients with rheumatoid arthritis who have comorbid fibromyalgia is associated more with tender joint counts than with patient global assessment or swollen joint counts: implications for assessment of inflammatory activity
Authors' conclusion
DAS28-ESR is elevated significantly in FM+ vs. FM- RA patients; pooled effect sizes were highest for TJC, followed by PATGL, SJC and ESR.
Study context
- Population
- Rheumatoid arthritis (RA) patients with vs without comorbid FM in 14 reports comparing DAS28-ESR and its four components14 reports
- Comparison
- RA with comorbid FM vs RA without FM
- Outcome
- DAS28-ESR and its four components (TJC, SJC, PATGL, ESR)
Methodological detailsPubMed search, pooled effect sizes
- PubMed search
- Pooled effect sizes
Pooled result
As reported in the abstract
FM+
5.3
median
FM-
4.2
median
- Large (≥0.8) in 10/14 comparisons
- pooled effect size (DAS28-ESR) 0.84 (95% CI 0.3–1.4)
- Large in 1/13 comparisons
- pooled effect size (swollen joint count (SJC)) 0.33 (95% CI −0.4 to 1.0)
- Large in 12/13 comparisons
- pooled effect size (tender joint count (TJC)) 1.27 (95% CI 0.01–2.5)
- Large in 7/13 comparisons
- pooled effect size (PATGL) 0.91 (95% CI −0.6 to 2.4)
- Large in 1/13 comparisons
- pooled effect size (erythrocyte sedimentation rate (ESR)) 0.07 (95% CI −0.6 to 0.7)
Original publication
Elevated DAS28-ESR in patients with rheumatoid arthritis who have comorbid fibromyalgia is associated more with tender joint counts than with patient global assessment or swollen joint counts: implications for assessment of inflammatory activity. Clin Exp Rheumatol. Published 23 October 2023. doi:10.
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