Systemic sclerosis & Raynaud's
Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis
Authors' conclusion
Combining selective IHC and unbiased gene expression analyses, this exploratory study highlights the potential for disease-relevant organ effects of FMT in SSc patients with GIT involvement.
Study context
- Population
- SSc patients with gastrointestinal tract (GIT) involvement
- Participants
- 9 patients
- Comparison
- Intestinal infusion of faecal microbiota transplantation (FMT) vs placebo
- FMTn = 5
- Placebon = 4reference
- Outcome
- Effects of FMT on duodenal mucosa (immunohistochemistry (IHC) and transcriptome)
Methodological detailsplacebo-controlled, duodenal biopsies, immunohistochemistry, whole biopsy transcriptome profiling
- Placebo-controlled
- Duodenal biopsies
- Immunohistochemistry
- Whole biopsy transcriptome profiling
Main finding
As reported in the abstract
Correlation of decline in podoplanin-positive cells with improved patient-reported lower GIT symptoms
r = 0.94
Correlation of decline in CD64-positive cells with improved patient-reported lower GIT symptoms
r = 0.89
Genes upregulated at both week 2 and week 16, including Matrix metalloproteinase-1
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Original publication
Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis. Rheumatology (Oxford). Published 23 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →