Systemic sclerosis & Raynaud's
Hyperspectral imaging in systemic sclerosis-associated Raynaud phenomenon
Authors' conclusion
Hyperspectral imaging is a feasible approach for SSc-RP quantification in the clinic setting. The RCS and CHFS values did not correlate with HSI parameters.
Study context
- Population
- Patients with SSc-RP and healthy controls recruited in the clinic setting; 92% women in their 40s
- Participants
- 13 vs 12
- Exposure
- SSc-RP patients vs healthy controls
- SSc-RPn = 13
- HCn = 12reference
- Outcome
- Hyperspectral imaging oxyHb, deoxyHb and O2 sat of fingertips at baseline and after cold challenge (0, 10, 20 min)
Methodological detailscase-control, cold provocation challenge, Mann-Whitney U test and mixed effects model
- Case-control
- Cold provocation challenge
- Mann-Whitney U test and mixed effects model
Main finding
As reported in the abstract
HSI oxygenation parameters
- Baseline deoxyHb higher and O2 sat lower in systemic sclerosis (SSc) patients vs HC
- p < 0.05
- Greater decline in oxyHb and O2 sat from baseline to time 0 after cold challenge, with distinct rewarming oxyHb, O2 sat and deoxyHb trajectories, in SSc patients vs HC
- p < 0.01
Observational data: associations, not effects.
Further findings
Correlation of hyperspectral imaging (HSI) changes after cold challenge with Raynaud Condition Score (RCS) or Cochin Hand Function Scale (CHFS) scores
- No significant correlations between oxyHb, deoxyHb and O2 sat level changes and RCS or CHFS scores
Original publication
Hyperspectral imaging in systemic sclerosis-associated Raynaud phenomenon. Arthritis Res Ther. Published 20 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →