Effects of Aging on Rheumatoid Factor and Anticyclic Citrullinated Peptide Antibody Positivity in Patients With Rheumatoid Arthritis
Authors' conclusion
Aging is an independent contributor for seronegative RA in patients who are female, have a nonsmoking history, and a BMI < 25.
Study context
- Population
- All consecutive patients with rheumatoid arthritis (RA) treated at Keio University Hospital, 2016–201783.4% women
- Participants
- 1,685 patients
- Exposure
- Rheumatoid factor (RF) and anti-CCP positivity by age at RA diagnosis
- Outcome
- RF and anti-CCP positivity by age at diagnosis, sex, smoking, BMI and family history
Methodological detailsconsecutive patients, single-centre, multivariable analysis
- Consecutive patients
- Single-centre
- Multivariable analysis
Main finding
As reported in the abstract
RF positivity by decade of age at diagnosis
80.5%, 84.2%, 81.1%, 78%, 74.6%, 62.6%, 51.4%
P < 0.001
Anti-CCP positivity by decade of age at diagnosis
79.9%, 87.4%, 81.7%, 74%, 70.5%, 60.2%, 37.1%
P < 0.001
Observational data: associations, not effects.
Further findings
Age and seropositivity in women (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age (RF)Age independently associated with seronegativity | 0.98 (0.97–0.99) | P < 0.001 | |
| Age (anti-CCP)Age independently associated with seronegativity | 0.97 (0.96–0.98) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Age and seropositivity with nonsmoking history (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age (RF)Age independently associated with seronegativity | 0.98 (0.97–0.99) | P < 0.001 | |
| Age (anti-CCP)Age independently associated with seronegativity | 0.97 (0.96–0.98) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Age and seropositivity with BMI < 25 (multivariable)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age (RF)Age independently associated with seronegativity | 0.98 (0.97–0.99) | P < 0.001 | |
| Age (anti-CCP)Age independently associated with seronegativity | 0.97 (0.97–0.98) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Original publication
Effects of Aging on Rheumatoid Factor and Anticyclic Citrullinated Peptide Antibody Positivity in Patients With Rheumatoid Arthritis. J Rheumatol. Published 1 November 2022. doi:10.
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