Adipocytokines and Associations With Abnormal Body Composition in Rheumatoid Arthritis
Authors' conclusion
Adipokines are associated with both excess adiposity and low lean mass in patients with RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA) from three cohorts; whole-body DXA appendicular lean mass and fat mass indices as age-, sex-, race- and ethnicity-specific Z scores
- Participants
- 419 patients
- Outcome
- Associations between adipokines (adiponectin, leptin, FGF-21) and body composition profiles
Methodological detailspooled data from three RA cohorts, linear and logistic regression adjusted for demographics and study cohort
- Pooled data from three RA cohorts
- Linear and logistic regression adjusted for demographics and study cohort
Main finding
As reported in the abstract
Adipokines and body composition
- Greater fat mass strongly associated with lower adiponectin and higher leptin and FGF-21 levels
- Higher adiponectin, leptin and FGF-21 levels independently associated with low lean mass
Observational data: associations, not effects.
Further findings
Prediction of low lean mass: adding adiponectin and leptin to model with demographics, study and body mass index (BMI)
- AUC with vs without adiponectin and leptin
- 0.75 vs. 0.66
Clinical correlates of adipokines
- Older age associated with higher levels of all adipokines
- Higher CRP associated with lower adiponectin and higher FGF-21 levels
Original publication
Adipocytokines and Associations With Abnormal Body Composition in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 31 October 2022. doi:10.
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