Rheumatoid arthritis

Racial Differences in Multimorbidity and Comorbidities in Rheumatoid Arthritis

Arthritis Care Res (Hoboken)Published Case-control study

Main finding · Multimorbidity ≥2 comorbiditiesResult — go to the resultAdjusted odds 2.19 95% CI 2.16–2.23

Authors' conclusion

Multimorbidity is a problem for all RA patients.

Study context

Population
Enrollees in OptumLabs Data Warehouse, 2010 to 2019 (mean age 59.6, 76% female)mean age 59.6, 76% female
Participants
154,391 vs 154,391
Comparison
Rheumatoid arthritis (RA) cases vs matched non-RA controls, within each race and ethnicity
  • RA casesn = 154,391
  • Controlsn = 154,391reference
Outcome
Multimorbidity (≥2 or ≥5 validated comorbidities), within each race and ethnicity
Methodological detailsmatched 1:1 on age, sex, race and ethnicity, region, index date of RA, and insurance coverage duration, logistic regression
  • Matched 1:1 on age, sex, race and ethnicity, region, index date of RA, and insurance coverage duration
  • Logistic regression

Main finding

Multimorbidity ≥2 comorbidities

Adjusted odds

2.19

95% CI 2.16–2.23

As reported in the abstract

Observational data: associations, not effects.

Further findings

Renal disease in White enrollees

P < 0.001

OutcomeAdjusted odds (95% CI)
Multimorbidity ≥5 comorbidities2.06 (2.02–2.09)
Valvular heart disease in Black and White enrollees
P < 0.001
Valvular heart disease in Black and White enrollees — Black: RA cases vs controls
3.2% versus 2.6%
Valvular heart disease in Black and White enrollees — White: RA cases vs controls
2.8% versus 2.2%

Multimorbidity ≥2/≥5 by race and ethnicity

Black enrollees (most), ≥2/≥5
73.1%, 34.3%
Asian enrollees (least), ≥2/≥5
52.4%, 17.3%

Original publication

Racial Differences in Multimorbidity and Comorbidities in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 31 October 2022. doi:10.1002/acr.25020

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