Electronic cigarette use and risk of incident rheumatoid arthritis and systemic lupus erythematosus in the all of us research program
Authors' conclusion
Current e-cigarette use was associated with an increased risk of RA or SLE.
Study context
- Population
- All of Us Research Program (version 8) participants; followed from enrollment up to 5 years or until October 1, 2023
- Exposure
- Current e-cigarette users vs matched non-users
- E-cigarette current usersn = 15,909
- Outcome
- Incident RA or SLE
- Follow-up
- Up to 5 years
Methodological detailsmatched by age, sex, race/ethnicity, enrollment year, and cigarette smoking status, Cox models adjusting for other potential confounders, smoking- and disease state-stratified analyses
- Matched by age, sex, race/ethnicity, enrollment year, and cigarette smoking status
- Cox models adjusting for other potential confounders
- Smoking- and disease state-stratified analyses
Main finding
As reported in the abstract
Each group vs matched non-usersEstimate (95% CI)
E-cigarette current users
IRR 1.54(1.05–2.26)
E-cigarette current users
aHR 1.49(1.01–2.20)
Observational data: associations, not effects.
Further findings
Stratified analyses (smoking status, disease)
- Risks higher among e-cigarette users than non-users who were past or current smokers, and elevated for both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), although with smaller sample sizes
Original publication
Electronic cigarette use and risk of incident rheumatoid arthritis and systemic lupus erythematosus in the all of us research program. Semin Arthritis Rheum. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →