COVID-19 vaccination in autoimmune diseases (COVAD) study: vaccine safety and tolerance in rheumatoid arthritis
Authors' conclusion
Despite the differences in AE frequency across different COVID-19 vaccines, all were well tolerated in patients with RA and were comparable to HCs, providing reassurance as to the safety of COVID-19 vaccination.
Study context
- Population
- Respondents to an online COVID-19 vaccination questionnaire (March-December 2021); RA patients mean (SD) age 50.7 (13.7) years, 74.2% women, 49.3% Caucasian
- Participants
- 9,462 complete respondents
- Exposure
- RA vs other autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and healthy controls
- RAn = 1,347
- Outcome
- Short-term COVID-19 vaccination-related AEs in RA
Methodological detailsonline self-reported questionnaire, multivariable regression
- Online self-reported questionnaire
- Multivariable regression
Main finding
As reported in the abstract
Vaccination-related AEs in RA
| Group | Value | Minor adverse events (AEs) | Major AEs |
|---|---|---|---|
| RA | 76.9% | 76.9% | 4.2% |
RA
Value76.9%
Minor adverse events (AEs)76.9%
Major AEs4.2%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| AEs, RA vs nrAIDsRAvs nrAIDsOverall AEs and minor AEs (both) | 0.7 (0.5–0.9) | |
| AEs, RA vs nrAIDsRAvs nrAIDsInjection site pain | 0.6 (0.5–0.8) | |
| 0.512Odds ratio (log scale) |
AEs, RA vs nrAIDs
- Similar major AE and hospitalization frequencies vs nrAIDs
AEs by RA activity
- Active and inactive RA had similar AE and hospitalization frequencies
AEs by vaccine
- AEs more frequent with BNT162b2 and mRNA-1273, less frequent with BBV152, vs the rest; major AE and hospitalization frequencies similar across vaccines
Minor AEs by MTX and HCQ use
- Patients on MTX and HCQ reported fewer minor AEs than those not on them
Original publication
COVID-19 vaccination in autoimmune diseases (COVAD) study: vaccine safety and tolerance in rheumatoid arthritis. Rheumatology (Oxford). Published 31 October 2022. doi:10.
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