Effect of Treatment Changes on Health-Related Quality of Life in Canadian Children With Juvenile Idiopathic Arthritis: Results From ReACCh-Out and CAPRI
Authors' conclusion
First-year improvements in HRQOL measured by JAQQ were similar in the 2017-2023 and 2005-2010 cohorts, but adjustment for baseline imbalances suggests greater HRQOL improvements in those with more severe disease in the later cohort.
Study context
- Population
- Newly diagnosed Canadian patients with juvenile idiopathic arthritis (JIA) who completed the JAQQ at enrollment and 1 year later
- Participants
- 478 vs 663
- Exposure
- JIA inception cohort 2017–2023 vs 2005–2010
- 2017-2023n = 478
- 2005-2010n = 663reference
- Outcome
- Mean change in JAQQ domain scores (health-related quality of life (HRQOL)) from baseline
- Follow-up
- 1 year
Methodological detailsmultivariable linear regression adjusted for baseline imbalances
- Multivariable linear regression adjusted for baseline imbalances
Main finding
As reported in the abstract
Improvement in total JAQQ score from baseline
2017-2023
0.97
95% CI 0.85–1.09
2005-2010
0.92
95% CI 0.82–1.02
Observational data: associations, not effects.
Further findings
csDMARD use by 1 year
bDMARD use by 1 year
Arthritis pain score, change from baseline to 1 year
- Pain scores improved significantly
- −2.07 vs −1.62, P = 0.03
Adjusted change in JAQQ domains, patients with ≥ 5 active joints (subgroup) · 1 year
- Greater improvements in the 2017-2023 cohort for all JAQQ domains, after adjusting for baseline imbalances
- β 0.28 for psychosocial to β 0.62 for gross motor
Original publication
Effect of Treatment Changes on Health-Related Quality of Life in Canadian Children With Juvenile Idiopathic Arthritis: Results From ReACCh-Out and CAPRI. J Rheumatol. Published 15 September 2025. doi:10.
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