Predictors of persisting pain in children with Juvenile Idiopathic Arthritis: a case control study nested in the ReACCh-Out cohort
Authors' conclusion
Among newly diagnosed children with JIA with moderate pain, female sex, lower overall quality of life, and higher enthesitis counts at baseline predicted development of persisting pain.
Study context
- Population
- Newly diagnosed children with Juvenile Idiopathic Arthritis (JIA) and moderate pain, Canadian ReACCh-Out inception cohort
- Participants
- 31 vs 118
- Comparison
- Moderate persisting pain vs moderate decreasing pain
- Casesn = 31
- Controlsn = 118reference
- Outcome
- Baseline predictors of persisting pain
- Follow-up
- Minimum 3 years
Methodological detailsunivariate and multivariate logistic regression, follow-up minimum 3 years
- Univariate and multivariate logistic regression
- Follow-up minimum 3 years
Main finding
As reported in the abstract
Baseline predictors of persisting pain (final multivariate model)
Enthesitis count at baseline, OR
1.40
95% CI 1.19–1.76
Female sex, OR
4.14
95% CI 1.33–16.83
Overall Quality of My Life (QoML) baseline score, OR
0.82
95% CI 0.69–0.98
Observational data: associations, not effects.
Further findings
Baseline characteristics
Female
RF-positive polyarthritis
Undifferentiated JIA
Oligoarthritis
Mean active joints Cases 11.4 · Controls 7.7
Sites of enthesitis Cases 4.6 · Controls 0.7
Mean
| Outcome | Cases | Controls |
|---|---|---|
| Mean pain score at baseline | 6.4 (SD 1.6) | 5.9 (SD 1.5) |
Original publication
Predictors of persisting pain in children with Juvenile Idiopathic Arthritis: a case control study nested in the ReACCh-Out cohort. Pediatr Rheumatol Online J. Published 16 September 2023. doi:10.
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