Presentation and outcome of pediatric lupus nephritis from a large single centre contemporary cohort in Eastern India
Authors' conclusion
Our study on a contemporary cohort of childhood LN highlights the importance of achieving CR and its feasibility.
Study context
- Participants
- 60 participants
- Outcome
- Treatment response in children with ≥2 years follow-up (n = 52)
- Follow-up
- At least 2 years
Methodological detailssingle-centre, observational, Median follow-up 50 (IQR: 28-82) months, All received steroids for induction; Mycophenolate Mofetil (MMF) sole induction agent in 48% (n = 29), CYC in 27% (n = 16); RTX added as rescue in 17% (n = 10)
- Single-centre
- Observational
- Median follow-up 50 (IQR: 28-82) months
- All received steroids for induction; MMF sole induction agent in 48% (n = 29), CYC in 27% (n = 16); RTX added as rescue in 17% (n = 10)
Main finding
As reported in the abstract
Complete response (CR)
46
88%
Partial response (PR)
3
6%
No response (NR)
3
6%
Observational data: associations, not effects.
Further findings
Baseline characteristics · diagnosis
- Median age at diagnosis, years (IQR 9-12)
- 11
- Mucocutaneous manifestation
- n = 54, 90%
- Edema
- n = 50, 83.3%
- Median 24-h urinary protein, mg/m²/day (IQR 795.4-1941.7)
- 1117.8
- Nephrotic range proteinuria
- 67% (n = 40)
- eGFR <90 mL/min/1.73 m²
- 75% (n = 45)
- Median eGFR, mL/min/1.73 m² (IQR 56-90)
- 71
- Low C3 and C4
- 82% (n = 49)
- Anti-dsDNA positive
- 63% (n = 38)
- Proliferative lupus nephritis (LN)
- 85% (n = 51)
- Class IV
- 57%, n = 34
- ANA positive in all
Renal flares
- Children with flares
- 36% (n = 22)
- Flare episodes
- 36
- Incidence
- 0.14/person-year
Death from serious infections
- Deaths
- 6 (10%)
- None had shown CR
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Presentation and outcome of pediatric lupus nephritis from a large single centre contemporary cohort in Eastern India. Lupus. Published 14 September 2023. doi:10.
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