Lupus & antiphospholipid syndrome
Effect of anti-P ribosomal and anti-NR2 antibodies on depression and cognitive processes in SLE: an integrated clinical and functional MRI study
Authors' conclusion
Anti-P was associated with brain network perturbation, which may be responsible for depressive symptoms in patients with SLE.
Study context
- Population
- Adult patients fulfilling the ACR/EULAR 2019 SLE criteria9% male
- Participants
- 33 patients
- Outcome
- Depressive symptoms (CES-D score): independent associations after correction for age, disease duration, disease activity and white matter lesion load
Methodological detailsintegrated clinical and functional MRI study
- Integrated clinical and functional MRI study
Main finding
As reported in the abstract
Anti-P serum level, β
0.32
p=0.049
Prednisone daily dose, β
0.38
p=0.023
Observational data: associations, not effects.
Original publication
Effect of anti-P ribosomal and anti-NR2 antibodies on depression and cognitive processes in SLE: an integrated clinical and functional MRI study. Lupus Sci Med. Published 2 November 2023. doi:10.
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