Vasculitis & polymyalgia rheumatica
Dysregulation of neutrophil oxidant production and interleukin-1–related cytokines in granulomatosis with polyangiitis
Authors' conclusion
Our data suggests that ROS production and regulation of inflammasomes in neutrophils from patients with GPA are disturbed
Study context
- Population
- Granulomatosis with polyangiitis (GPA) patients with disease flare, NEUTROVASC cohortGPA patients with flare
- Participants
- 72 patients
- Exposure
- Active GPA vs same patients in remission or healthy controls
- Active GPAn = 72
- Outcome
- ROS production by neutrophils in whole blood
Main finding
As reported in the abstract
Neutrophil ROS production
- Robust defect in reactive oxygen species (ROS) production by neutrophils in active GPA vs healthy controls, independent of GC treatment
Observational data: associations, not effects.
Further findings
Serum IL-1-related cytokines
- Significantly increased in GPA, particularly with kidney involvement; returned to normal after remission
Inflammasome-related proteins
- Significantly dysregulated in neutrophil cytosol and serum from GPA patients
Original publication
Dysregulation of neutrophil oxidant production and interleukin-1–related cytokines in granulomatosis with polyangiitis. Rheumatology (Oxford). Published 8 November 2023. doi:10.
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