Vasculitis & polymyalgia rheumatica
Down-regulated FcγRII expression on plasma cells is associated with the disease activity of ANCA-associated vasculitis
Authors' conclusion
There is a down-regulation of FcγRIIB/CD32B expression on B cells in patients with AAV, which is associated with the disease activity of AAV.
Study context
- Population
- Patients with ANCA-associated vasculitis (AAV) in active stage and in remission, and healthy donors
- Exposure
- Active AAV vs AAV in remission vs healthy donors
- Outcome
- FcγRII/CD32 expression on B cell subsets and its correlation with disease activity
Methodological detailsflow cytometry
- Flow cytometry
Main finding
As reported in the abstract
FcγRII/CD32 expression on plasma cells
- Significantly lower in active AAV than in AAV in remission and healthy donors
- Negatively correlated with BVAS and percentages of cellular crescents in renal biopsies
Observational data: associations, not effects.
Original publication
Down-regulated FcγRII expression on plasma cells is associated with the disease activity of ANCA-associated vasculitis. Rheumatology (Oxford). Published 16 September 2022. doi:10.
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