Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?
Primary result · Knee joint loading during walkingResult — go to the resultAdjusted mean internal knee extension moment, % less 27%Authors' conclusion
Among older adults with knee OA and varus alignment, long-term lower extremity strength training results in significant increases in strength but does not significantly alter most measures of knee joint loading during walking relative to an attention control group.
Study context
- Population
- Adults with knee varus alignment and medial tibiofemoral osteoarthritis (OA)
- Participants
- 39 vs 49
- Comparison
- 18 months of strength training vs attention control
- Strength trainingn = 39
- Controln = 49reference
- Primary endpoint
- Knee joint loads during walking (peak internal knee abduction moment, peak knee compressive force, internal knee extension moment)
- Follow-up
- 18 months
Methodological detailsattention control
- Attention control
Primary result
Knee joint loading during walking
Adjusted mean internal knee extension moment, % less
27%
Padjusted = 0.03
As reported in the abstract
Further findings
Increase in muscle strength · greater increases in strength
P < 0.05
Quadriceps
Hamstrings
Hip abductors
Original publication
Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait? Arthritis Care Res (Hoboken). Published 10 March 2026. doi:10.
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