Lupus & antiphospholipid syndrome
Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry
Authors' conclusion
AsA patients with SLE exhibited higher IGS than EA patients in all cell types regardless of autoantibody status, with enhanced expression of genetically associated genes upstream of the IGS potentially contributing. AsA, along with the IGS in NK cells, anti-dsDNA and complement, independently influenced SLE disease activity.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) stratified by self-identified ancestry; isolated CD14+ monocytes, CD19+ B cells, CD4+ T cells and Natural Killer (NK) cells
- Comparison
- SLE patients of Asian ancestry vs European ancestry
- Outcome
- Expression of IFN gene signatures (type 1 and type 2 IFN response)
Methodological detailsgene set variation analysis, machine learning
- Gene set variation analysis
- Machine learning
Main finding
As reported in the abstract
IGS enrichment (IFN core and IFNA2)
- Asian ancestry (AsA) showed greater enrichment in interferon (IFN) core and IFNA2 IGS vs European ancestry (EA) in all cell types examined, with and without autoantibodies
- AsA showed higher expression of genes upstream of the IGS than EA
Further findings
Features classifying disease activity (machine learning (ML) feature importance)
- IGS expression in NK cells, anti-dsDNA, complement levels and AsA status contributed to disease activity
Original publication
Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry. RMD Open. Published 14 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →