Differential gut microbiota and inflammatory cytokines contribute to IgA vasculitis
Authors' conclusion
IgAV is characterised by disturbances of gut microbiota composition and an imbalance in inflammatory cytokines.
Study context
- Population
- Mice transplanted with gut microbiota from children with Immunoglobulin A vasculitis (IgAV) or healthy controls; children with IgAV and healthy controls (HCs)
- Comparison
- Mice receiving gut microbiota from children with IgAV vs from healthy controls
- Outcome
- Gut microbiota composition and serum cytokines in mice receiving faecal microbiota from children with IgAV (rIMb) vs HCs (rHMb)
Methodological detailsfaecal microbiota transplantation into mice, integration of mouse and human sequence data
- Faecal microbiota transplantation into mice
- Integration of mouse and human sequence data
Main finding
As reported in the abstract
- IgAV-specific amplicon sequence variants (ASVs) detected in recipient IgAV microbiota (rIMb) mice
- 55
- Healthy-child-specific ASVs detected in recipient healthy microbiota (rHMb) mice
- 35
- Alcaligenaceae discriminated rIMb from rHMb mice; abundance decreased in rIMb vs rHMb
- p<0.05
Original publication
Differential gut microbiota and inflammatory cytokines contribute to IgA vasculitis. Clin Exp Rheumatol. Published 8 April 2025. doi:10.
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