Serum elafin levels in patients with IgA vasculitis: a prospective case-control study
Authors' conclusion
Serum elafin levels were significantly elevated during the active stage of IgAV and may serve as a potential biomarker for disease activity, particularly in patients with visceral involvement.
Study context
- Population
- Pediatric patients with Immunoglobulin A vasculitis (IgAV), single centrepaired remission data
- Participants
- 51 vs 54
- Comparison
- Paediatric IgAV vs healthy controls; active stage vs remission
- IgAVn = 51
- Healthy controlsn = 54reference
- Outcome
- Serum elafin levels (enzyme-linked immunosorbent assay (ELISA))
Methodological detailssingle-centre, age- and sex-matched controls, paired intra-individual comparison (active vs remission)
- Single-centre
- Age- and sex-matched controls
- Paired intra-individual comparison (active vs remission)
Main finding
As reported in the abstract
Serum elafin level
| Group | Value | Range |
|---|---|---|
| IgAV | mean 45.43 (SD 11.11) ng/dL | 34.02-69.28 |
| Healthy controls | mean 27.44 (SD 12.66) ng/dL | 0.01-41.84 |
Value
IgAVmean 45.43 (SD 11.11) ng/dL
Healthy controlsmean 27.44 (SD 12.66) ng/dL
Range
IgAV34.02-69.28
Healthy controls0.01-41.84
- IgAV vs Healthy controls: P < 0.001
Observational data: associations, not effects.
Further findings
- ROC analysis of serum elafin for distinguishing active IgAV
- 35.38 ng/dL · cut-off · sensitivity 86.2% · specificity 77.8%
Serum elafin, active stage vs remission
- Highest concentrations during active disease stage
- P < 0.001
Serum elafin by organ involvement
- Significantly higher with visceral involvement (gastrointestinal, renal or scrotal)
- P < 0.05
- No significant association with isolated skin or joint involvement
Correlation of serum elafin with inflammatory markers
- Erythrocyte sedimentation rate (ESR), r = 0.418
- P = 0.001
- C-reactive protein (CRP), r = 0.547
- P < 0.001
- Neutrophil-to-lymphocyte ratio, r = 0.355
- P = 0.002
- Systemic immune-inflammation index, r = 0.347
- P = 0.003
Original publication
Serum elafin levels in patients with IgA vasculitis: a prospective case-control study. Pediatr Rheumatol Online J. Published 29 September 2025. doi:10.
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