Spondyloarthritis & psoriatic arthritis
Differences in transcriptional changes in psoriasis and psoriatic arthritis skin with immunoglobulin gene enrichment in psoriatic arthritis
Authors' conclusion
Immunoglobulin genes are upregulated in PsA but not in psoriasis skin lesions.
Study context
- Population
- Patients with PsA, patients with psoriasis without PsA, and healthy controls
- Comparison
- Transcriptional changes in PsA skin vs psoriasis skin (without PsA), each vs healthy controls
- Outcome
- Transcriptional changes in uninvolved and lesional skin
Methodological detailsbulk tissue sequencing, comparison with existing dataset (GSE121212), validation cohort
- Bulk tissue sequencing
- Comparison with existing dataset (GSE121212)
- Validation cohort
Main finding
As reported in the abstract
Transcriptional changes in skin
- Uninvolved skin in psoriasis shared transcriptional changes with lesional skin in psoriasis, but uninvolved skin in PsA did not
- Most transcriptional changes in psoriasis and PsA lesional skin were shared
- Immunoglobulin genes upregulated in PsA lesional skin specifically
- Transcription factor POU2F1, which regulates immunoglobulin gene expression, enriched in PsA lesional skin; confirmed in validation cohort
- Psoriasis and PsA datasets could not be directly compared as different analysis methods were used
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Differences in transcriptional changes in psoriasis and psoriatic arthritis skin with immunoglobulin gene enrichment in psoriatic arthritis. Rheumatology (Oxford). Published 3 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →