Spondyloarthritis & psoriatic arthritis
Effects of secukinumab on synovitis and enthesitis in patients with psoriatic arthritis: 52-week clinical and ultrasound results from the randomised, double-blind ULTIMATE trial with open label extension
Authors' conclusion
ULTIMATE showed consistent improvements in clinically and ultrasound-assessed synovitis and enthesitis and sustained clinical efficacy through week 52 in patients with PsA treated with secukinumab and placebo switched to secukinumab.
Study context
- Population
- Biologic-naïve patients with psoriatic arthritis (PsA) with active power Doppler ultrasonography (PDUS) synovitis and clinical enthesitis and inadequate response to csDMARDs144 completed week 52
- Participants
- 166 patients
- Comparison
- Secukinumab 150 mg or 300 mg sc vs placebo to week 12, then all open-label secukinumab to week 52
Methodological detailsdouble-blind, placebo-controlled, Phase 3
- Double-blind
- Placebo-controlled
- Phase 3
Primary result
As reported in the abstract
GLOESS (synovitis) · up to week 12
- Significant reduction in GLOESS with secukinumab vs placebo at week 12; stable to week 52; placebo switchers reached a similar reduction at week 24, stable thereafter
Further findings
Spondyloarthritis Research Consortium of Canada (SPARCC) enthesitis index · up to week 12
- Significant reduction with secukinumab vs placebo at week 12, sustained to week 52
Global OMERACT PDUS enthesitis score
- Numerically lower with secukinumab vs placebo switchers in first two periods; some stability in third period in both groups
Clinical responses across key PsA domains · up to week 52
- Improvements in both groups up to week 52
Original publication
Effects of secukinumab on synovitis and enthesitis in patients with psoriatic arthritis: 52-week clinical and ultrasound results from the randomised, double-blind ULTIMATE trial with open label extension. Semin Arthritis Rheum. Published 19 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →