Spondyloarthritis & psoriatic arthritis
Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways
Authors' conclusion
Chemokines and their receptors are upregulated in lesional PsA skin but relatively unchanged in uninvolved PsA skin. In contrast to previous psoriasis studies, ACKR2 was not upregulated in uninvolved PsA skin.
Study context
- Population
- Participants with psoriatic arthritis (PsA) (paired lesional and uninvolved skin biopsies) and healthy controls9 healthy control (HC) and 9 paired PsA samples
- Participants
- 9 / 9 / 9
- Comparison
- Lesional and uninvolved PsA skin vs HC skin
- Lesional PsAn = 9
- Uninvolved PsAn = 9
- HCn = 9reference
- Outcome
- Transcriptome of PsA skin vs HC skin and ACKR2 expression in PsA skin
Methodological detailstranscriptomic (RNA sequencing), paired lesional and uninvolved skin, validation by qPCR and RNAscope
- Transcriptomic (RNA sequencing)
- Paired lesional and uninvolved skin
- Validation by qPCR and RNAscope
Main finding
As reported in the abstract
- PsA uninvolved skin was transcriptionally similar to HC skin
- Lesional PsA skin enriched in epidermal and inflammatory genes
- Lesional PsA skin enriched in chemokine-mediated signalling pathways; uninvolved skin was not
- ACKR2 upregulated in lesional PsA skin; unchanged in uninvolved vs HC skin
- ACKR2 expression confirmed by qPCR; RNAscope showed strong ACKR2 expression in suprabasal epidermis of PsA lesions
Original publication
Cutaneous lesions in psoriatic arthritis are enriched in chemokine transcriptomic pathways. Arthritis Res Ther. Published 2 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →