Diagnostic Yield of Computed Tomography for Cancer Detection in a Tertiary Referral Population of Idiopathic Inflammatory Myositis Patients
Authors' conclusion
In a tertiary referral cohort of IIM patients, CT imaging has a wide range of diagnostic yield and frequency of false positives for contemporaneous cancer.
Study context
- Population
- Patients with idiopathic inflammatory myopathy (IIM) in a tertiary referral populationComputed tomography (CT) scans
- Participants
- 1,011 vs 657
- Exposure
- Diagnostic yield of chest CT and abdomen/pelvis CT for cancer screening/surveillance across IIM subtypes, myositis-specific autoantibody strata and age
- CT chestn = 1,011
- CT abdomen/pelvisn = 657
- Outcome
- Overall diagnostic yield (cancers diagnosed/tests performed)
- Follow-up
- Within first 3 years since IIM symptom onset
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Diagnostic yield (CT detecting cancer)
Observational data: associations, not effects.
Further findings
Diagnostic yield in DM, anti-transcription intermediary factor 1γ (highest)
False positives, ASyS (highest)
Diagnostic yield, age <40 years at IIM onset
False-positive rate, age <40 years at IIM onset
| Outcome | CT chest | CT abdomen/pelvis |
|---|---|---|
| False positives, IMNM (highest on chest CT) | 4.4% | — not stated in the abstract |
— not stated in the abstract
Original publication
Diagnostic Yield of Computed Tomography for Cancer Detection in a Tertiary Referral Population of Idiopathic Inflammatory Myositis Patients. Arthritis Care Res (Hoboken). Published 19 April 2023. doi:10.
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