Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature
Authors' conclusion
Anti-SAE positive DM is a rare subgroup associated with typical skin features but a potentially diffuse rash, a mild myopathy. Interstitial lung disease defines an organizing pneumonia pattern. Cancer associated DM prevalence is five times that of the general population.
Study context
- Population
- Patients with DM and sera positive for anti-SAE antibody, 19 centres
- Participants
- 49 vs 85
- Exposure
- Anti-SAE-positive DM vs anti-SAE-negative DM
- Anti-SAE-positive DMn = 49
- Anti-SAE-negative DMn = 85reference
- Outcome
- Clinical characteristics, cancer prevalence and muscle pathology of anti-SAE-positive DM
Methodological detailsmulticentre (19 centres), comparison with anti-SAE-negative DM
- Multicentre (19 centres)
- Comparison with anti-SAE-negative DM
Main finding
As reported in the abstract
Clinical characteristics of anti-SAE-positive DM
- Women
- 84%
- Typical skin involvement
- 96%
- Calcinosis
- 10%
- Ulceration
- 18%
- Necrosis
- 12%
- Widespread skin rash
- 35%
- Muscular disease
- 84%
- Muscle weakness, Medical Research Council (MRC) scale (mild)
- 4 (3, 5)
- Dysphagia
- 39%
- ILD, mainly organizing pneumonia pattern
- 21%
- Dyspnoea
- 26%
- Cancer-associated myositis (responsible for the majority of deaths; prevalence five times that of the general population)
- 16%
- IVIG therapy during the course of the disease
- 51%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Comparison with anti-SAE-negative DMAnti-SAE-positive DM vs Anti-SAE-negative DM · less muscle weakness | P = 0.02 |
| Comparison with anti-SAE-negative DMAnti-SAE-positive DM vs Anti-SAE-negative DM · milder muscle weakness | P = 0.006 |
| Comparison with anti-SAE-negative DMAnti-SAE-positive DM vs Anti-SAE-negative DM · lower creatinine kinase levels | P < 0.0001 |
| Comparison with anti-SAE-negative DMAnti-SAE-positive DM vs Anti-SAE-negative DM · less dyspnoea | P = 0.003 |
Original publication
Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature. Rheumatology (Oxford). Published 3 April 2023. doi:10.
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