Sjögren's disease & overlap diseases
Diagnostic utility of a second minor salivary gland biopsy in patients with suspected Sjögren's syndrome: A retrospective cohort study
Authors' conclusion
We observed a low concordance between 2 MSGB in patients with suspected pSS in our study. Despite this variability, performing a second MSGB changed the initial diagnosis in only a minority of the patients and was particularly useful when clinical manifestations had deeply evolved.
Study context
- Population
- Patients with suspected primary or secondary Sjögren's syndrome who had 2 minor salivary gland biopsies, Brest University Hospital, 1990–2015
- Participants
- 93 patients
- Exposure
- First positive vs first negative minor salivary gland biopsy
- First positive minor salivary gland biopsy (MSGB)n = 23
- First negative MSGBn = 70reference
- Outcome
- Concordance between the 2 MSGB and modifications of diagnosis after the second MSGB
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Concordance between the results of the 2 biopsies (low), κ
0.34
Diagnosis changed after second MSGB, cases (second MSGB always guided by new specific clinical manifestations)
10
Mean time between the 2 MSGB, years
5.7±4.3
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics of first positive vs first negative MSGBFirst positive MSGB vs First negative MSGB · renal involvement more often | P < 0.05 |
| Characteristics of first positive vs first negative MSGBFirst positive MSGB vs First negative MSGB · hypergammaglobulinemia more often | P = 0.01 |
| Characteristics of first positive vs first negative MSGBFirst positive MSGB vs First negative MSGB · anti-SSA antibodies more often | P < 0.05 |
| Characteristics of first positive vs first negative MSGBFirst positive MSGB vs First negative MSGB | P < 0.01 |
- Characteristics of first positive vs first negative MSGB: positive second biopsy (focus score ≥ 1 or Chisholm>2) more often
Original publication
Diagnostic utility of a second minor salivary gland biopsy in patients with suspected Sjögren's syndrome: A retrospective cohort study. Joint Bone Spine. Published 13 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →