Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3
Authors' conclusion
BME is the most responsive lesion to treatment with TNFi in axJSpA followed by IEC and then erosion. Validation according to the OFISA framework demonstrates that the JAMRIS-all slice and SPARCC instruments have comparable performance characteristics.
Study context
- Population
- Youth with spondyloarthritis (SpA) who had sacroiliac joint (SIJ) MRI prior to and after tumor necrosis factor inhibitor (TNFi), two longitudinal cohorts
- Participants
- 60 participants2 cohorts
- Comparison
- JAMRIS-all slice vs Spondyloarthritis Research Consortium of Canada (SPARCC) selected slices
- Outcome
- Longitudinal construct validity: descriptive variables, reliability and responsiveness of MRI SIJ lesion scores
Methodological detailstwo longitudinal cohorts, readers blinded to timepoint, 7 readers (5 MSK radiologists, 2 rheumatologists), OFISA framework
- Two longitudinal cohorts
- Readers blinded to timepoint
- 7 readers (5 MSK radiologists, 2 rheumatologists)
- OFISA framework
Performance
As reported in the abstract
- Major contributor to change in inflammatory lesion scores was bone marrow edema (BME) followed by in an erosion cavity (IEC); differences between the two instruments minimal
- Change in structural lesions: minimal differences between SPARCC and JAMRIS-all slice
- Reliability for detection of change scores and responsiveness comparable between SPARCC and JAMRIS-all slice
- Combining inflammatory lesion scores did not enhance responsiveness vs BME alone
- Mean (SD) duration between scans 46.6 (47.1) weeks
Original publication
Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3. Semin Arthritis Rheum. Published 9 June 2026. doi:10.
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