Core Set of Responsive and Discriminatory Measures for Use in Pragmatic Trials of Youth With Axial Juvenile Spondyloarthritis
Authors' conclusion
A set of measures was developed for youth with axJSpA.
Study context
- Population
- Youth (aged 8–18 years) with axial juvenile spondyloarthritis (axJSpA) initiating tumor necrosis factor inhibitor (TNFi) therapyevaluable cohort
- Participants
- 57 participants
- Outcome
- Core set of measures for axJSpA: responsiveness (standardized response mean, SRM) and discrimination (SMD)
- Follow-up
- 12 weeks
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Final axJSpA core set: responsiveness and discrimination
- Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference, standardized response mean (SRM)
- 0.77
- PROMIS pain interference, SMD
- 0.5
- Sacroiliac joint inflammation score, SRM
- 1.02
- Sacroiliac joint inflammation score, SMD
- 0.52
- PROMIS mobility, SRM
- 0.83
- PROMIS mobility, SMD
- 0.75
- Patient global well-being, SRM
- 0.88
Observational data: associations, not effects.
Further findings
Clinical response (change ≥2 in PGA) with TNFi · 12 weeks
- Clinical response
- 70.2%
Continued magnetic resonance imaging (MRI) inflammation · 12 weeks
- Continued MRI inflammation
- 58%
- Of those, reported moderate clinical improvement
- 77%
Overall and composite disease activity measures
- All tested, except physician global assessment, had high SRM and SMD
Subgroups by biologic sex and overweight status
- Improvement in MRI inflammation score greater in male patients
- Improvement in PROMIS pain interference and mobility greater in those with normal BMI
Original publication
Core Set of Responsive and Discriminatory Measures for Use in Pragmatic Trials of Youth With Axial Juvenile Spondyloarthritis. Arthritis Care Res (Hoboken). Published 23 June 2025. doi:10.
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