Spondyloarthritis & psoriatic arthritis
Derivation and Internal Validation of a Disease‐Specific Cardiovascular Risk Prediction Model for Patients With Psoriatic Arthritis and Psoriasis
Authors' conclusion
Traditional cardiovascular risk factors alone are effective in predicting cardiovascular risk in patients with PsD.
Study context
- Population
- Participants with psoriatic disease (PsA and psoriasis) without a history of cardiovascular events, 1992–202085 developed CV events
- Participants
- 1,336 participants
- Comparison
- Base model vs expanded models adding 8 PsD-related factors
- Outcome
- Nonfatal and fatal cardiovascular events (five-year risk prediction)
- Follow-up
- five-year
Methodological detailsprospective cohort, Least Absolute Shrinkage and Selection Operator (LASSO) penalized regression with 10-fold cross-validation
- Prospective cohort
- LASSO penalized regression with 10-fold cross-validation
Performance
As reported in the abstract
Discrimination of base model
| Test or model | AUC |
|---|---|
| Base model | 85.5 (95% CI 81.9-89.1) |
Base model
AUC85.5 (95% CI 81.9-89.1)
Further findings
- Sensitivity analysis excluding lipid lowering and antihypertensive treatments (number of damaged joints selected in expanded model)
- 85.5 (95% CI 82.0-89.1) · AUC
Sensitivity analysis excluding lipid lowering and antihypertensive treatments (number of damaged joints selected in expanded model)
- Did not improve risk discrimination vs base model
Original publication
Derivation and Internal Validation of a Disease‐Specific Cardiovascular Risk Prediction Model for Patients With Psoriatic Arthritis and Psoriasis. Arthritis Rheumatol. Published 19 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →