Spondyloarthritis & psoriatic arthritis
Defining a genetic background for bamboo spine and axial spondyloarthritis
Authors' conclusion
Our results indicate that HLA-B27 positivity, ERAP1 haplotype 3 and -6, and being male confer a significant risk for developing bamboo spine.
Study context
- Population
- Patients with axSpA fulfilling the modified New York criteria followed in MARS (MARmara Spondyloarthritis) clinic
- Participants
- 192 patients
- Comparison
- axSpA with bamboo spine vs axSpA without bamboo spine
- Outcome
- Association of ERAP1 and ERAP2 SNP haplotypes with development of bamboo spine
Methodological detailssingle-centre, ERAP1 and ERAP2 polymorphisms by real-time PCR (TaqMan SNP Genotyping Assay); HLA-B genotypes by LABTypeTM SSO method
- Single-centre
- ERAP1 and ERAP2 polymorphisms by real-time PCR (TaqMan SNP Genotyping Assay); HLA-B genotypes by LABTypeTM SSO method
Main finding
As reported in the abstract
ERAP1 and ERAP2 haplotypes/SNPs and bamboo spine
- ERAP1 haplotype 3 significantly more prevalent in bamboo spine, adjusted for HLA-B27 status
- P<0.05
- Haplotype 3 and −6 significantly more prevalent exclusively in HLA-B27 (+) patients
- P<0.05
Further findings
Clinical factors and bamboo spine
- Male gender associated with increased risk of bamboo spine
- P < 0.001
- HLA-B27 positivity associated with increased risk of bamboo spine
- P < 0.05
- Peripheral arthritis significantly less prevalent with bamboo spine
- P < 0.05
Original publication
Defining a genetic background for bamboo spine and axial spondyloarthritis. Joint Bone Spine. Published 17 January 2025. doi:10.
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