Spondyloarthritis & psoriatic arthritis
Incidence and Risk of Infections in Patients With Radiographic Axial Spondyloarthritis Receiving Biologic Therapies: A Prospective Observational Study Using the KOBIO Registry
Authors' conclusion
The infection rate was 39.39 events/1000 PY, with respiratory tract infections being most common, followed by HZ. Significant risk factors for the occurrence of infection in patients with r-axSpA treated with biologics included advanced age, female sex, IHD, DM with complications, CKD, and peripheral arthritis.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA) in the KOBIO registry who initiated or switched to a biologic agent, December 2012–December 20237107.67 person-years (PY) of follow-up
- Participants
- 2,129 patients
- Outcome
- First occurrence of any infection, mild to severe, classified by organ system
Methodological detailsregistry-based (KOBIO), Cox proportional hazard regression adjusted for confounders, Poisson distribution for rates
- Registry-based (KOBIO)
- Cox proportional hazard regression adjusted for confounders
- Poisson distribution for rates
Main finding
As reported in the abstract
Infection rate (events/1000 PY)
Overall infection rate, events/1000 PY
39.39
Upper and lower respiratory tract infections (most common), per 1000 PY
25.89
Herpes zoster, per 1000 PY
6.13
Observational data: associations, not effects.
Original publication
Incidence and Risk of Infections in Patients With Radiographic Axial Spondyloarthritis Receiving Biologic Therapies: A Prospective Observational Study Using the KOBIO Registry. J Rheumatol. Published 15 January 2025. doi:10.
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