Spondyloarthritis & psoriatic arthritis
Clinical and MRI remission in axial spondyloarthritis: one-year outcomes and predictors from the TRACE treat-to-target study with secukinumab
An erratum to this article was published (Arthritis Res Ther, 17 Jul 2026 ↗)
Authors' conclusion
A 1-year secukinumab-based treat-to-target strategy in axSpA patients provided rapid and sustained clinical improvement, MRI-inflammation reduction and structural remodelling. BMI, sex, HLA-B27 and clinical/MRI disease activity predicted clinical and MRI-remission.
Study context
- Population
- Biologic-naïve patients with active axial spondyloarthritis (axSpA)54 completed w56
- Participants
- 90 patients
- Outcome
- Clinical remission (ASDAS < 1.3)
- Follow-up
- Week 56
Methodological detailsinvestigator-initiated, multicentre, treat-to-target, single-arm, dose-escalation, multivariable logistic regression
- Investigator-initiated
- Multicentre
- Treat-to-target
- Single-arm
- Dose-escalation
- Multivariable logistic regression
Main finding
As reported in the abstract
Patients achieving w56 clinical remission
32
59%
Observational data: associations, not effects.
Further findings
Total MRI-inflammation (sacroiliac joint (SIJ) + spine), mean · week 0 to 56
- Decreased from mean 39.0 to 6.7
MRI remission (SPARCC-SIJ ≤ 1 + CANDEN-spine ≤ 2) · week 56
- Achieving w56 MRI remission
- 43%
Structural lesion remodelling on MRI · week 4 to 56
- Evident by w4 and sustained through w56: erosion decreased, fat lesion and backfill increased, new bone formation/ankylosis unchanged
- MRI-inflammation and structural lesion changes comparable irrespective of w56 clinical remission status and treatment at w56
Independent baseline predictors of remission
- w16 clinical remission: ASDAS and BMI
- w56 clinical remission: none
- w16 MRI remission: female sex, lower MRI-inflammation and higher MRI-erosion score
- w56 MRI remission: lower MRI-inflammation and HLA-B27 positivity
- Multivariable logistic regression
Original publication
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