DAS28(3)CRP is a reliable measure of disease activity in pregnant women with rheumatoid arthritis
Authors' conclusion
This pilot study found that DAS28(3)CRP is a reliable measure of disease activity in pregnant women with RA.
Study context
- Population
- Pregnant women with rheumatoid arthritis (RA) recruited from an Obstetric Rheumatology clinic, and age-matched non-pregnant women with RA
- Participants
- 27 vs 20
- Exposure
- DAS28(3)CRP vs power Doppler US scores in pregnant vs age-matched non-pregnant women with RA
- Pregnantn = 27
- Non-pregnantn = 20reference
- Outcome
- Performance of DAS28(3)CRP vs MSK-US power Doppler scores (small joints of hands and feet) for disease activity
Methodological detailsage-matched non-pregnant comparison, musculoskeletal ultrasound (MSK-US) with power Doppler as gold standard
- Age-matched non-pregnant comparison
- MSK-US with power Doppler as gold standard
Main finding
As reported in the abstract
Correlation between DAS28(3)CRP and PD scores
Pregnancy, T2: r
0.82 (95% CI [0.42, 0.95])
p<0.01
Pregnancy, T3: r
0.68 (95% CI [0.38, 0.86])
p<0.01
Postpartum: r
0.84 (95% CI [0.60, 0.94])
p<0.01
Non-pregnancy (weaker): r
0.47 (95% CI [0, 0.77])
p<0.05
Observational data: associations, not effects.
Original publication
DAS28(3)CRP is a reliable measure of disease activity in pregnant women with rheumatoid arthritis. Clin Exp Rheumatol. Published 1 February 2023. doi:10.
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