Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk
Authors' conclusion
Both IgA1 and IgA2 ACPA are present in RA at-risk individuals, but only IgA1 ACPA are associated with the progression to RA.
Study context
- Population
- Healthy controls, individuals at-risk for RA and patients with RA
- Exposure
- IgA1 and IgA2 anticitrullinated protein antibody (ACPA) positive vs negative RA at-risk individuals; healthy controls and patients with RA as comparators
- Outcome
- Prevalence of IgA ACPA in RA at-risk individuals and association with transition to RA
- Follow-up
- 14 months
Methodological detailscross-sectional and longitudinal measurements, second, independent cohort
- Cross-sectional and longitudinal measurements
- Second, independent cohort
Main finding
As reported in the abstract
- Approximately two-thirds of RA at-risk individuals positive for serum IgA1 and IgA2 ACPA, in levels comparable to IgG ACPA positive patients with RA
- IgA1, but not IgA2, ACPA positivity associated with transition from RA at-risk state to RA within 14 months
Observational data: associations, not effects.
Further findings
IgA1 ACPA levels during transition to RA (longitudinal)
- IgA1 ACPA levels declined at RA onset and thereafter during early RA; decline confirmed in a second, independent cohort
Original publication
Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk. RMD Open. Published 30 January 2023. doi:10.
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